Coronaviral PLpro proteases and the immunomodulatory roles of conjugated versus free Interferon Stimulated Gene product-15 (ISG15)Review Published on 2022-12-012023-07-09 Journal: Seminars in cell & developmental biology [Category] COVID19(2023년), [키워드] coronavirus Deubiquitinating enzymes DUB HERC5 interferon ISG15 MERS-CoV papain-like proteases PLPro SARS-CoV SARS-CoV2 ubiquitin Ubiquitin E3 ligases Ubiquitin-Like proteins Ubiquitin-specific proteases. USP [DOI] 10.1016/j.semcdb.2022.06.005 PMC 바로가기 [Article Type] Review
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylationArticle Published on 2022-10-152022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] 치료제, [키워드] A549 cell activated Activation acute respiratory syndrome Affect and SARS-CoV-2 papain-like protease. contribute coronavirus coronavirus disease COVID-19 Curcumin decrease dose-dependent manner enzyme expression expression level function help immunomodulator Infection innate immune responses interferon interferon-stimulated gene Interferon-stimulated gene 15 kDa investigated ISG15 ISGylation kDa Modification monomer occur Papain-like protease pathogen Prevent Protein reduce SARS-CoV-2 severe COVID-19 Spread substrate suggested treated Treatment [DOI] 10.1016/j.bbrc.2022.08.003 PMC 바로가기
SARS-CoV-2 Papain-Like Protease: Structure, Function and InhibitionArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral agent antiviral immune response antivirals coronavirus COVID-19 derivatives Epidemic function Host immune response immune immune response in viral inhibition involved ISG15 less MERS-CoV motif other coronaviruses Papain-like protease posttranslational modifications protease protease inhibitors protease inhibitors. Replication SARS-CoV-1 SARS-CoV-2 Structure targets variants of concern variants of SARS-CoV-2 Viral protein [DOI] 10.1002/cbic.202200327 PMC 바로가기
Expedient Synthesis of Ubiquitin-like Protein ISG15 Tools through Chemo-Enzymatic Ligation Catalyzed by a Viral Protease LbproArticle Published on 2022-10-042023-07-10 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), [키워드] Chemical Protein Synthesis ISG15 ligation ubiquitin Ubiquitin-Like Protein. [DOI] 10.1002/anie.202206205 PMC 바로가기
Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 InfectionArticle Published on 2022-09-302022-11-16 Journal: Viruses [Category] SARS, 치료법, [키워드] A549 analysis biopsy boost case-control study CBL confirmation COVID-19 COVID-19 patients displaying double-stranded expression gene expression profile highlighting host response Hub human cell line IFN-stimulated gene IFN-γ Immunotherapy in vitro infected with SARS-CoV-2 Infection ISG ISG15 ISGs ISGs. JAK2 liver lung lung cell MAP2K6 mice murine model MX1 MX2 OAS1 pathway patients positive correlation positive patients Responding RUNX3 SARS-CoV-2 SARS-COV-2 infection Stat1 target the patient tracheal treated upregulation Viral load was performed [DOI] 10.3390/v14102180 PMC 바로가기
IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RAArticle Published on 2022-09-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] 1,25-dihydroxy vitamin D3 activated acute respiratory syndrome analyses Analysis applied autoimmune conditions Bacteremia Bacterial Bacterial infection Bacterial infections Bioinformatics analysis Biomarker caused Cell cell membrane CIBERSORT conducted coronavirus COVID-19 Cytoscape database dataset datasets DEGs dendritic cell dendritic cells dendritic cells. differentially expressed differentially expressed gene disease DNA drug target Effectiveness examined expression FIVE functional enrichment Functional enrichment analysis GBP1 gene network GeneMANIA Genes global pandemic HERC5 humans identify Ifi44 IFI44L IFIT3 IFIT5 IFN signaling IFN signaling pathway IFN-α/β Immune cell infiltration immune cells Immune escape immune evasion immune system Immunological response Infection infections infiltration Intersection ISG15 KEGG mechanism miRNA molecular mechanism molecular target NLR OAS1 oxidative phosphorylation pathogenic bacteria pathway Patient platform positive correlation PPI network prevalent proliferation promote regulate Regulation Rheumatoid rheumatoid arthritis risk factor ROC curves RSAD2 Rtp4 SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease signaling pathway Staphylococcus Staphylococcus aureus target the SARS-CoV-2 therapeutic viral infection viral replication virus were used YY1 [DOI] 10.3389/fimmu.2022.1013322 PMC 바로가기
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like proteaseSARS-CoV-2 파파인 유사 프로테아제의 알로스테릭 부위에서 복합체 내 천연 페놀 화합물의 항바이러스 활성Article Published on 2022-08-112022-09-11 Journal: Communications Biology [Category] SARS, 변종, 신약개발, 치료제, [키워드] antiviral activity antiviral immune response cleavage complex Compound Concentration coronavirus COVID-19 infections cysteine Cytopathic effect down-regulated functions Host immune responses inhibited innate immune responses ISG15 molecular interaction Mutation natural phenolic compound Papain Papain-like protease PLPro protease Protein SARS-CoV-2 Support ubiquitin variants of SARS-CoV-2 Vero Cell Vital function X-ray [DOI] 10.1038/s42003-022-03737-7 PMC 바로가기 [Article Type] Article
Repurposing the antibacterial drugs for inhibition of SARS-CoV2-PLpro using molecular docking, MD simulation and binding energy calculation분자 도킹, MD 시뮬레이션 및 결합 에너지 계산을 사용하여 SARS-COV2-PLPRO의 억제를위한 항균제를 재사용Article Published on 2022-08-012022-08-31 Journal: Molecular diversity [Category] SARS, 신약개발, [키워드] acetic acid Amino acid amino acids Antibacterial Antibacterial compounds aromatic rings benzofuran best binding energy cleavage collected complex Compound conserved docked downregulating downregulation drug effective effective inhibitor feature filtered function GRL0617 Host hydrophobic hydrophobic interaction immune system indol inhibitor Interaction interferon interferon-stimulated gene IRF3 ISG15 key amino acid key amino acids MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation non-structural protein novel corona virus Papain Papain-like protease Papain-like protease (PLpro) PLPro produced promoted protease Protein protein-ligand Proteins removal Replication reported repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 novel corona virus. SARS-CoV2 similarity stability type I interferon Viral viral growth Zinc ZINC database [DOI] 10.1007/s11030-021-10325-0 PMC 바로가기 [Article Type] Article
Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ωSARS-CoV-2에 대한 국소 인터페론 반응의 연령별 비교는 IFN-ε 및 -ω에 대한 역할을 제안합니다Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated Adults age anti-SARS-CoV-2 basal Basal transcription characterized children component components contribute develop diagnostic disease effective expression Genes highest Hospitalization IFN IFN response IFN-stimulated genes IFN-α IFN-ε IFN-λ1 IFN-ω IFNs individual infected individuals Infection Innate immunity interferon ISG ISG15 ISGs Mild Mild disease nasopharyngeal cell nasopharyngeal cells non-infected Occurrence Older overexpressed Protective quantified recent recognize relative expression response resulting risk role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals severe COVID-19 significantly higher starting swabs Symptom Transcription transcriptomic analysis type I type I and III IFNs type I interferon type I interferon. type III up-regulated [DOI] 10.3389/fimmu.2022.873232 PMC 바로가기 [Article Type] Article